Airway infl ammation in asthma : current and future targets and therapies
نویسنده
چکیده
To provide an overview of airway inflammation in asthma. To review current management guidelines’ recommendations for the use of anti-inflammatory therapies in asthma. To discuss current treatment options for airway inflammation in asthma. To outline unmet needs for treating airway inflammation in asthma. To describe novel targets for treating airway inflammation in asthma based on current knowledge.
منابع مشابه
Conclusion: Airway hyperresponsiveness in asthma: its measurement and clinical significance.
or indirect challenges with inhaled mannitol 2 or exercise 3 is important in establishing a correct diagnosis. This is particularly true in excluding asthma as a diagnosis in patients with symptoms that suggest asthma, but are caused by another condition. This is because airway hyperresponsiveness measurements are very sensitive in determining a diagnosis of asthma (therefore, they have a high ...
متن کاملRacial differences influence health-related quality-of-life measurements.
We thank Dr Medford for his interest in our recent article in CHEST (August 2011). 1 Prior studies by our group demonstrated that direct instillation of either Mycoplasma pneumoniae or recombinant M pneumoniae community-acquired respiratory distress syndrome toxin (rCARDS Tx) causes a lymphocytic perivascular response and eventually induces a robust peribronchial infl ammation in both rodents a...
متن کاملDetection of Intracellular Markers in Airway Inflammation a Biochemical and Immunocytochemical Study in Induced Sputum
6 ABBREVIATIONS APAAP alkaline phosphatase-anti-alkaline phosphatase AUC area under curve BAL bronchoalveolar lavage BSA bovine serum albumin BUD budesonide COPD chronic obstructive pulmonary disease CTAB N-cetyl-N,N,N,-trimethylammonium bromide DTE dithioerythritol DTT dithiothreitol EG2, EG1 monoclonal antibodies against ECP and/or EPX/EDN ECP eosinophil cationic protein EPO eosinophil peroxi...
متن کاملThe Role of Systemic Infl ammation in COPD
Abstract Chronic obstructive pulmonary disease (COPD) is defi ned as a preventable and treatable disease with signifi cant extrapulmonary effects. Many of the extrapulmonary effects of COPD are thought to be mediated by systemic infl ammation. Local infl ammation has always been appreciated as part of the COPD disease process; however, it is becoming clear that the infl ammatory response is als...
متن کاملOccupational allergy and asthma in the seafood industry – emerging issues
Increased demand for seafood and its functional by-products has been associated with a concomitant rise in fi shing and aquaculture activities. This increased consumption and processing of seafood is associated with more frequent allergic health problems among seafood processors. This overview of occupational allergies and asthma in seafood exposed workers illustrates the changing nature of the...
متن کامل